Figure 3.
![Figure 3. A model for ATXN3 in the editing of Ub chains on nuclear targets. The model combines the recent work of Scaglione et al. (2011) with earlier studies showing that ATXN3, a deubiquitinating enzyme, has a role in regulating gene expression. Like the proposed role of ATXN3 in the Ube2W/CHIP ubiquitination cycle of misfolded proteins, it is postulated that ATXN3 also regulates a ubiquitination cycle involved in assembly/disassembly of transcription complexes in the nucleus. ↑[Q]n indicates an increased interaction of expanded polyQ ATXN3 with a yet to be identified nuclear protein involved in regulation of transcription.](https://cdn.rupress.org/rup/content_public/journal/jcb/197/2/10.1083_jcb.201105092/4/jcb_201105092_fig3.jpeg?Expires=1767780143&Signature=IQT9fxN95kveQxMHLh6DeVsXaAsU959EwL6gJEK9C9cjAiXa7LsbRqAw5QzAkJ60DO3O1bU6Gh3zWRuDixIivpGZpEoZC3vBlG-a-UmyuzjShruS3SQF7zE~yXTAdcahSsIoSgCoho9w58gp-Mf0Q8xvDfmyQ3u3VHXvtw~w2B51KMLGfy-O268qRcRGikgpa0BBGEMvBumQgYK4siVG3vR-zlrN6V0Hqq1OIR5Oui-XPi7fs2NdcTiO09EYZVLw4z3QKuKbwKnvECkEd66Lr953j3lBPdNVo3tc-6SdkFRPV7CpuYGZnAOlEANFR893v-FmUSPtQFqzL~5j3rE3qg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
A model for ATXN3 in the editing of Ub chains on nuclear targets. The model combines the recent work of Scaglione et al. (2011) with earlier studies showing that ATXN3, a deubiquitinating enzyme, has a role in regulating gene expression. Like the proposed role of ATXN3 in the Ube2W/CHIP ubiquitination cycle of misfolded proteins, it is postulated that ATXN3 also regulates a ubiquitination cycle involved in assembly/disassembly of transcription complexes in the nucleus. ↑[Q]n indicates an increased interaction of expanded polyQ ATXN3 with a yet to be identified nuclear protein involved in regulation of transcription.
