The centrosome cycle of animal cells. Main events in the centrosome cycle are highlighted along with the key players that have been implicated in each process. Green-filled regions represent the centrin-positive distal regions of the centriole. As cells exit mitosis the daughter centriole disengages from the mother centriole, losing its orthogonal connection (centriole disengagement). Upon disengagement, the daughter centriole is connected to the mother by a flexible linker (pink strands). Centriole assembly factors accumulate in S phase and new centrioles are formed and gradually elongate throughout S and G2. At the G2/M transition the flexible linker that holds the centriole pairs together is lost (linker dissolution) and the centrioles accumulate more PCM (maturation) and constitute the poles of the mitotic spindle.