Figure 9.
Figure 9. FSGS disease mutation K255E inhibits actin assembly on membranes. (a) Negative-stain EM showing bundling of actin filaments by WT and K255E α-actinin-4. Bar, 200 nm. (b) WT and K255E are recruited to stripped membranes. (c) K255E did not support actin assembly on stripped membranes and inhibited the activity of WT α-actinin-4. (b and c) Bar, 2 µm.

FSGS disease mutation K255E inhibits actin assembly on membranes. (a) Negative-stain EM showing bundling of actin filaments by WT and K255E α-actinin-4. Bar, 200 nm. (b) WT and K255E are recruited to stripped membranes. (c) K255E did not support actin assembly on stripped membranes and inhibited the activity of WT α-actinin-4. (b and c) Bar, 2 µm.

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