Figure 2. Structure and function of chimeric adhesion constructs. Fusions between the cytoplasmic tail of cadherins and α-catenin, or between cadherin and actin-binding proteins, have been used to probe the connection between the CCC and the actin cytoskeleton. Note: Not all of the chimeras used in each experiment are depicted in this schematic; only those discussed in this review are shown. (A) Chimeric fusion constructs of mammalian E-cadherin and αE-catenin (Nagafuchi et al., 1994; Imamura et al., 1999). (B) Chimeric fusions of Drosophila DE-cadherin and α-catenin (Pacquelet and Rørth, 2005). (C) Chimeric fusion of mammalian αE-catenin and formin-1(IV) (Kobielak et al., 2004). (D) Chimeric fusion of mammalian E-cadherin and EPLINα (Abe and Takeichi, 2008).
Figure 2.

Structure and function of chimeric adhesion constructs. Fusions between the cytoplasmic tail of cadherins and α-catenin, or between cadherin and actin-binding proteins, have been used to probe the connection between the CCC and the actin cytoskeleton. Note: Not all of the chimeras used in each experiment are depicted in this schematic; only those discussed in this review are shown. (A) Chimeric fusion constructs of mammalian E-cadherin and αE-catenin (Nagafuchi et al., 1994; Imamura et al., 1999). (B) Chimeric fusions of Drosophila DE-cadherin and α-catenin (Pacquelet and Rørth, 2005). (C) Chimeric fusion of mammalian αE-catenin and formin-1(IV) (Kobielak et al., 2004). (D) Chimeric fusion of mammalian E-cadherin and EPLINα (Abe and Takeichi, 2008).

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