Model of the spatiotemporal regulation of Moe activity throughout the successive steps of the cell cycle. The cell cortex that comprises the plasma membrane and the underlying cytoskeleton works as a single functional unit to control cell morphology. (A) Two pathways temporally and spatially control coupling of actin filaments to the plasma membrane through the regulation of Moe activity. (B) Redistribution of the Pp1-87B phosphatase at mitosis entry is likely to promote a burst of Slik-dependent phosphorylation of Moe at early mitotic stages and then ensures Moe down-regulation at the end of division and in interphase. The localized enrichment of Skittles and Pten acts to increase PI(4,5)P2 levels at the anaphase equator, further promoting Moe recruitment at the equator and release at the polar cortex to allow cell elongation. The same players are involved in the transient recruitment and activation of Moe at the cortex of polar blebs, which is important for their efficient retraction. P, phosphorylation.
