Figure 5. Aurora B hyperactivation in Bub1-overexpressing cells drives chromosome missegregation and aneuploidization. (A) Chromosome segregation analysis after treatment with 2.5 nM ZM447439 or constitutive co-overexpression of BubR1. The average of three independent primary MEFs is shown. Error bars represent SEM. (B) Chromosome counts on metaphase spreads of P5 wild-type, Bub1T85, and Bub1T264 MEFs after treatment with 2.5 nM ZM447439 or constitutive co-overexpression of BubR1. The average of three independent lines is shown and error bars represent SEM.
Figure 5.

Aurora B hyperactivation in Bub1-overexpressing cells drives chromosome missegregation and aneuploidization. (A) Chromosome segregation analysis after treatment with 2.5 nM ZM447439 or constitutive co-overexpression of BubR1. The average of three independent primary MEFs is shown. Error bars represent SEM. (B) Chromosome counts on metaphase spreads of P5 wild-type, Bub1T85, and Bub1T264 MEFs after treatment with 2.5 nM ZM447439 or constitutive co-overexpression of BubR1. The average of three independent lines is shown and error bars represent SEM.

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