Parkin recruitment leads to selective mitophagy. Cytosolic parkin is selectively recruited to uncoupled or dysfunctional mitochondria. The outer membrane protein kinase Pink1 functions upstream of Parkin and may play a role in sensing mitochondrial damage and Parkin recruitment. The ubiquitination activity of Parkin was not directly examined in this study, but it will be important to determine whether it mono- or poly-ubiquinates its substrates. The recognition of Parkin-associated mitochondrial fragments by LC3-positive autophagosome requires Atg5. Fusion with lysosomes leads to the total degradation and clearance of the damaged mitochondria. p, phosphorylation; ub, ubiquitin.