A scheme of SLAIN2-linked +TIP network and its biological role. Different types of +TIP interactions are indicated by different colors. The potential direct EB1–ch-TOG interaction based on the data from other species (Rehberg and Gräf, 2002; Wolyniak et al., 2006; Kronja et al., 2009) is not depicted. SLAIN2-dependent interactions enhance ch-TOG accumulation at the MT tip. ch-TOG, in turn, promotes processive MT growth that is required for proper MT organization.