FOCAL POINT Michael Gotthardt (left), Katharina da Silva Lopes (right), and colleagues (not shown) create knockin mice expressing a fluorescently tagged version of the giant muscle scaffold protein titin. The researchers analyze titin's dynamics in muscle cells and find that the protein is surprisingly mobile—after photobleaching segments of cardiac myofibrils (arrowheads, center image), titin fluorescence recovers within 14 hours (right). The authors suggest that titin can detach from sarcomeres, move freely by diffusion, and reattach elsewhere in the myofibril. / PHOTO COURTESY OF UTA WRACKMEYER

FOCAL POINT Michael Gotthardt (left), Katharina da Silva Lopes (right), and colleagues (not shown) create knockin mice expressing a fluorescently tagged version of the giant muscle scaffold protein titin. The researchers analyze titin's dynamics in muscle cells and find that the protein is surprisingly mobile—after photobleaching segments of cardiac myofibrils (arrowheads, center image), titin fluorescence recovers within 14 hours (right). The authors suggest that titin can detach from sarcomeres, move freely by diffusion, and reattach elsewhere in the myofibril.

PHOTO COURTESY OF UTA WRACKMEYER

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