Figure 2.
Figure 2. TRAF2 is required for the transduction of CD40 death signals. HeLa/CD40mT6 cells were transfected with TRAF2, TRAF3, or control siRNA and either lysed for the assessment of TRAF knockdown efficacy by immunoblotting (A) or exposed to 1 µg/ml soluble CD154 before evaluation of apoptosis (B). (C) Knockdown of TRAF2 in EJ bladder carcinoma cells confers resistance to apoptosis induced by soluble CD154 in the presence of 10 µg/ml CHX. Mean values (±SD) from three independent experiments are shown (error bars).

TRAF2 is required for the transduction of CD40 death signals. HeLa/CD40mT6 cells were transfected with TRAF2, TRAF3, or control siRNA and either lysed for the assessment of TRAF knockdown efficacy by immunoblotting (A) or exposed to 1 µg/ml soluble CD154 before evaluation of apoptosis (B). (C) Knockdown of TRAF2 in EJ bladder carcinoma cells confers resistance to apoptosis induced by soluble CD154 in the presence of 10 µg/ml CHX. Mean values (±SD) from three independent experiments are shown (error bars).

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