Focal Point Caroline Laplante (left) and Laura Nilson (right) determined how loss of the protein Echinoid (Ed) helps cells at the leading edge of a migrating epidermal sheet find their position. The image at the top right shows dorsal closure in a normal embryo in which the amnioserosa stops making Ed. But in the embryo at the bottom right, the amnioserosa continues to make part of Ed during dorsal closure, and the cells at the leading edge fail to elongate in the correct direction. / PHOTOS COURTESY OF IRENE REYNOLDS TEBBS (LEFT) AND JOHN COMISKEY (CENTER)

Focal Point Caroline Laplante (left) and Laura Nilson (right) determined how loss of the protein Echinoid (Ed) helps cells at the leading edge of a migrating epidermal sheet find their position. The image at the top right shows dorsal closure in a normal embryo in which the amnioserosa stops making Ed. But in the embryo at the bottom right, the amnioserosa continues to make part of Ed during dorsal closure, and the cells at the leading edge fail to elongate in the correct direction.

PHOTOS COURTESY OF IRENE REYNOLDS TEBBS (LEFT) AND JOHN COMISKEY (CENTER)

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