Nucleotide substitution preferences and rate of Ig hypermutation, Ig gene conversion, and mutations of ambiguous origin at 2 wk after AID virus infection in wild-type and mutant cells. (A) Nucleotide substitution preferences deduced from Ig hypermutation in the VJ_λ sequences (seq) of cells carrying the indicated genotype at 2 wk after AID virus infection. O/E, ectopic overexpression of AID. (B) AID-induced nucleotide substitution preferences from ambiguous (Amb) mutations, which are attributable to either Ig hypermutation or Ig gene conversion, are shown. (C) Rate of Ig hypermutation (PM), Ig gene conversion (GC), and mutations of ambiguous origin at 2 wk after AID virus infection. Error bars indicate SEM.