Figure 2.
Homozygous mutantcriptoF78A/F78Aembryos initiate gastrulation but subsequently arrest development. Morphology of wild-type embryos (A–D) and criptoF78A/F78A mutant litter mates (A′–D′) dissected at 7.5 (A and A′), 8.5 (B and B′), 9.5 (C and C′), and 10.5 (D and D′) dpc. Both anterior and posterior structures that are absent in cripto-null mutants (Ding et al., 1998; Liguori et al., 2003) can be clearly recognized at up to 8.5 dpc but subsequently deteriorate (C′ and D′). Bars, 40 μm.