Figure 6. scFv-EM48 alleviates the motor deficits of N171-82Q mice. (A) Footprint tracings of wild-type (WT), N171-82Q mice (HD), and N171-82Q mice injected with adenoviral scFv-EM48 (HD + scFv) or an adenoviral vector (HD + control). (B) Mean stride lengths (in millimeters) of the mice in A show that the abnormal gait seen in N171-82Q mice is partially reversed by adenoviral scFv-EM48. (C) Accelerating RotaRod testing of wild-type (WT) and N171-82Q mice (HD) demonstrates an improvement in RotaRod performance (time on the rod) for N171-82Q mice (HD + scFv) that had received adenoviral scFv-EM48 injections in their striatum. In all trials, n = 9–11 mice. P < 0.05 as compared with N171-82Q mice injected with adenoviral vector control (HD + control). (D) Survival plot and body weight (in grams) of wild-type (WT), N171-82Q (HD), and N171-82Q mice injected with adenoviral scFv-EM48 (HD + scFv) or an adenoviral vector (HD + control). The data are presented as means ± standard error. *, P < 0.05; **, P < 0.01.
Figure 6.

scFv-EM48 alleviates the motor deficits of N171-82Q mice. (A) Footprint tracings of wild-type (WT), N171-82Q mice (HD), and N171-82Q mice injected with adenoviral scFv-EM48 (HD + scFv) or an adenoviral vector (HD + control). (B) Mean stride lengths (in millimeters) of the mice in A show that the abnormal gait seen in N171-82Q mice is partially reversed by adenoviral scFv-EM48. (C) Accelerating RotaRod testing of wild-type (WT) and N171-82Q mice (HD) demonstrates an improvement in RotaRod performance (time on the rod) for N171-82Q mice (HD + scFv) that had received adenoviral scFv-EM48 injections in their striatum. In all trials, n = 9–11 mice. P < 0.05 as compared with N171-82Q mice injected with adenoviral vector control (HD + control). (D) Survival plot and body weight (in grams) of wild-type (WT), N171-82Q (HD), and N171-82Q mice injected with adenoviral scFv-EM48 (HD + scFv) or an adenoviral vector (HD + control). The data are presented as means ± standard error. *, P < 0.05; **, P < 0.01.

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