Figure 1. Schematic diagram of INPP3B... | Rockefeller University Press

Figure 1.

Schematic diagram of INPP3B dependent BCR clustering. Initial antigen recognition by the BCR activates INPP5B, which hydrolyzes PIP2 in the plasma membrane. This promotes local F-actin disassembly via regulation of cofilin and ezrin, enabling BCRs to coalesce into microclusters.

Schematic diagram of INPP3B dependent BCR clustering. Initial antigen recognition by the BCR activates INPP5B, which hydrolyzes PIP₂ in the plasma membrane. This promotes local F-actin disassembly via regulation of cofilin and ezrin, enabling BCRs to coalesce into microclusters.