The proposed model showing SNX27–retromer assembly directly interacts with MT1-MMP and mediates its recycling to invadopodia. MT1-MMP and MT2-MMP reside on distinct endosomal domains. Retromer and SNX27 localize on the subdomains of the sorting endosomes carrying MT1-MMP and MT2-MMP. This sorting machinery selectively recycles MT1-MMP and recognizes the cargo by directly interacting with its cytoplasmic tail.
Figure 8.

The proposed model showing SNX27–retromer assembly directly interacts with MT1-MMP and mediates its recycling to invadopodia. MT1-MMP and MT2-MMP reside on distinct endosomal domains. Retromer and SNX27 localize on the subdomains of the sorting endosomes carrying MT1-MMP and MT2-MMP. This sorting machinery selectively recycles MT1-MMP and recognizes the cargo by directly interacting with its cytoplasmic tail.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal