Figure S5.
Signatures of positive selection in the CXXC motif of the Yippee domain of MIS18α. (A) Annotated structural prediction model of mouse MIS18α (MmMIS18α), generated automatically by FREEDA and visualized in PyMOL without any manual modifications. Orange: Yippee domain, magenta: highly likely adaptive residues (probability ≥ 0.9). (B) Enlarged CXXC motifs with the S57 residue (blue) within motif 1. Green: conserved cysteine residues. (C) Snippet of the multiple sequence alignment of CXXC motif 1 in Murinae. Dark gray: highly conserved residues, gray: less conserved residues, white: non-synonymous substitutions.

Signatures of positive selection in the CXXC motif of the Yippee domain of MIS18α. (A) Annotated structural prediction model of mouse MIS18α (MmMIS18α), generated automatically by FREEDA and visualized in PyMOL without any manual modifications. Orange: Yippee domain, magenta: highly likely adaptive residues (probability ≥ 0.9). (B) Enlarged CXXC motifs with the S57 residue (blue) within motif 1. Green: conserved cysteine residues. (C) Snippet of the multiple sequence alignment of CXXC motif 1 in Murinae. Dark gray: highly conserved residues, gray: less conserved residues, white: non-synonymous substitutions.

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