Aurora kinases differ in the number of recurrently changing residues. (A–C) Recurrently changing residues, mapped onto reference coding sequences, are not detected in AURKA (A) and AURKB (B), as compared with AURKC (C). Orange frames: protein kinase domain. Structural models highlight high structural conservation of Aurora protein kinase domains (orange). Parts of the AURKA N-terminus were cropped to allow better visualization and comparison of kinase domains.