Figure 3. Na current with shifted... | Rockefeller University Press

Figure 3.

$Na+current with shifted biophysical properties is proportionally larger and contributes more charge than its conductance fraction in single cells. (A and B) The ratio of the shifted INa peak-to-baseline INa peak (A; black) and the fraction of charge carried by the shifted INa subpopulation QNa (B; black) are shown as a function of the shifted INa conductance fraction (fNa). (C and D) The shifted INa ratio (C; black) and shifted QNa ratio (D; black) are shown as a function of the shifted INa-to-baseline INa conductance fraction ratio (fNa/(1 − fNa)). In all panels, the dashed line represents the expected fraction or ratio, based on the proportion of the shifted INa conductance.$

Na ⁺ current with shifted biophysical properties is proportionally larger and contributes more charge than its conductance fraction in single cells. (A and B) The ratio of the shifted I_Na peak-to-baseline I_Na peak (A; black) and the fraction of charge carried by the shifted I_Na subpopulation Q_Na (B; black) are shown as a function of the shifted I_Na conductance fraction (f_Na). (C and D) The shifted I_Na ratio (C; black) and shifted Q_Na ratio (D; black) are shown as a function of the shifted I_Na-to-baseline I_Na conductance fraction ratio (f_Na/(1 − f_Na)). In all panels, the dashed line represents the expected fraction or ratio, based on the proportion of the shifted I_Na conductance.

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