Figure 3. Histone-evoked P2XR7 currents... | Rockefeller University Press

Figure 3.

Histone-evoked P2XR7 currents are increased in low Ca2+conditions. (A) Representative trace of current versus time recorded from a Xenopus oocyte 24–48 h after nuclear injection of plasmid cDNA encoding mouse P2XR7. Histones were applied in low Ca2+ solution and washed with high Ca2+. (B) P2XR7 histone currents in high and low Ca2+ (Ave ± SEM, n = 5–9 animals, 19–26 cells, * P < 0.0001 by unpaired Student’s t test).

Histone-evoked P2XR7 currents are increased in low Ca ²⁺ conditions. (A) Representative trace of current versus time recorded from a Xenopus oocyte 24–48 h after nuclear injection of plasmid cDNA encoding mouse P2XR7. Histones were applied in low Ca²⁺ solution and washed with high Ca²⁺. (B) P2XR7 histone currents in high and low Ca²⁺ (Ave ± SEM, n = 5–9 animals, 19–26 cells, * P < 0.0001 by unpaired Student’s t test).