Force–Ca2+responsiveness, tension-cost, and Ktrin skinned multi-cellular preparations. (A) Average Hill fit parameters of Ca2+ dependent force in Sham (open bars) and AOB (closed bars). (B) Average maximum ATPase consumption rate, tension-cost, and Ktr, the rate of force redevelopment following a rapid release–restretch maneuver, (n = 8 hearts per group; 25°C). Approximately three muscles were studied per heart. Subsequently, multiple muscle data were averaged to derive a single average datum per heart. *P = 0.05. Individual P vales: Fmax: P = 0.522; EC50: P = 0.338; Hill parameter: P = 0.128; ATPase max: P = 0.023; tension-cost: P = 0.005; Ktr: P = 0.015.
Figure 8.

Force–Ca 2+ responsiveness, tension-cost, and K tr in skinned multi-cellular preparations. (A) Average Hill fit parameters of Ca2+ dependent force in Sham (open bars) and AOB (closed bars). (B) Average maximum ATPase consumption rate, tension-cost, and Ktr, the rate of force redevelopment following a rapid release–restretch maneuver, (n = 8 hearts per group; 25°C). Approximately three muscles were studied per heart. Subsequently, multiple muscle data were averaged to derive a single average datum per heart. *P = 0.05. Individual P vales: Fmax: P = 0.522; EC50: P = 0.338; Hill parameter: P = 0.128; ATPase max: P = 0.023; tension-cost: P = 0.005; Ktr: P = 0.015.

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