Figure 6.
![Skinned myocyte Ca2+activated force development. (A) Representative skinned isolated myocyte fragment mounted in the experimental chamber using optical glue (SL = 2.2 μm; room temperature; 10 μm calibration bar). (B) Average force–[Ca2+] relationships in Sham and AOB. (C) Average Hill parameters obtained in the Sham (open bars) and AOB (closed bars) groups. Force was normalized to cross-sectional area (Sham n = 7 hearts; AOB n = 7 hearts). Approximately six myocytes were studied per heart. Subsequently, multiple muscle data were averaged to derive a single average datum per heart. *P = 0.05 (Fmax P = 0.005; Hill parameter P = 0.614; EC50 P = 0.664).](https://cdn.rupress.org/rup/content_public/journal/jgp/155/6/10.1085_jgp.202213288/1/jgp_202213288_fig6.png?Expires=1767708778&Signature=N2kNmPfq3lyRjOI2hz7BWOO0yKKtbWJQvwtEooUMs7UsUDXZA3pfijrtuidqH8Mcido7--I1oD1SK1tnUkLVx7IAV2M0fdTc1hnovdxYWwxjc0BA9fQhHPsGiLQGssau0GOQe3T2NqD22~2llYYXiS6K-Ba78LWUfYAB4GxgWlgjGjT4Qa3I~vFczXL8nluCVeqqMxnkZLorgbRFRFoKx2vAf2ot9VQdUee9iBeNw3-egqjPH88CtitDdFK~8gK1nj4NK-E4SZMOm6zXbtnuVEebdq23NpO99PFTXPFwzwWZahAX6BfLq~irLTwvtnPw8XyGXPdiWasFhAhsapqJdw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Skinned myocyte Ca 2+ activated force development. (A) Representative skinned isolated myocyte fragment mounted in the experimental chamber using optical glue (SL = 2.2 μm; room temperature; 10 μm calibration bar). (B) Average force–[Ca2+] relationships in Sham and AOB. (C) Average Hill parameters obtained in the Sham (open bars) and AOB (closed bars) groups. Force was normalized to cross-sectional area (Sham n = 7 hearts; AOB n = 7 hearts). Approximately six myocytes were studied per heart. Subsequently, multiple muscle data were averaged to derive a single average datum per heart. *P = 0.05 (Fmax P = 0.005; Hill parameter P = 0.614; EC50 P = 0.664).