Figure 6.
Visualization of RIC-3 binding motifs in the MX segment and in the MA–M4 transition. (a) Intracellular view of the pentameric 5-HT3A structure. MX-helix is in magenta space filling representation, and amino acids W347, R349, and L353 of MX are in yellow. (b) Intracellular view with the MA–M4 transition in cyan and orange, and residues W447, R449, and L454 of MA-M4 are in orange, left; view parallel to the membrane in addition with MX segment in magenta and yellow as in a, middle; and intracellular view with the same color representation, right (PDB ID 6W1J; Basak et al., 2020).

Visualization of RIC-3 binding motifs in the MX segment and in the MA–M4 transition. (a) Intracellular view of the pentameric 5-HT3A structure. MX-helix is in magenta space filling representation, and amino acids W347, R349, and L353 of MX are in yellow. (b) Intracellular view with the MA–M4 transition in cyan and orange, and residues W447, R449, and L454 of MA-M4 are in orange, left; view parallel to the membrane in addition with MX segment in magenta and yellow as in a, middle; and intracellular view with the same color representation, right (PDB ID 6W1J; Basak et al., 2020).

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