Figure 1.

Domain structure of the 5-HT 3A receptor. (a) Schematic of a single subunit illustrating the organization of the three domains, extracellular (gray), transmembrane (green) with four α-helical segments (M1 through M4), and intracellular (blue and magenta) with a 17 amino acid long MX-helix and a MA helix of 31 amino acids in length continuous with the subsequent M4 transmembrane helix. (b and c) Ribbon representation of a single subunit and pentameric receptor (PDB ID 4PIR; Hassaine et al., 2014). Colors as in a. All views parallel to the membrane plane.

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