Transcriptomic analysis assessing the effect of cMyBP-C ablation in hiPSC-ECT on genes involved in NMD. (A and B) Log fold change vs. −log FDR volcano plots of cMyBP-C+/+ vs. cMyBP-C+/− (A), and cMyBP-C+/+ vs. cMyBP-C−/− (B), and a heat map comparing gene expression in cMyBP-C+/+, cMyBP-C+/−, and cMyBP-C−/− hiPSC-ECTs of genes involved in the NMD pathway. (C) In volcano plots, differentially expressed genes (FDR < 0.05) are plotted as red dots. In heat maps (C), red indicates upregulated genes, while blue indicates genes that are downregulated. Z-scores >15 are highlighted in bright red.
Figure S5.

Transcriptomic analysis assessing the effect of cMyBP-C ablation in hiPSC-ECT on genes involved in NMD. (A and B) Log fold change vs. −log FDR volcano plots of cMyBP-C+/+ vs. cMyBP-C+/− (A), and cMyBP-C+/+ vs. cMyBP-C−/− (B), and a heat map comparing gene expression in cMyBP-C+/+, cMyBP-C+/−, and cMyBP-C−/− hiPSC-ECTs of genes involved in the NMD pathway. (C) In volcano plots, differentially expressed genes (FDR < 0.05) are plotted as red dots. In heat maps (C), red indicates upregulated genes, while blue indicates genes that are downregulated. Z-scores >15 are highlighted in bright red.

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