Figure 7.
cTnI-ND,Tnni3−/−hearts showed unchanged LVEDV but flatter LV EDPVR in comparison with that of WT hearts. (A) The representative LV P-V loops of ex vivo working hearts at 5, 10, and 20 mmHg preloads illustrate the larger fraction shortening/stroke volume of cTnI-ND,Tnni3−/− hearts than that of WT hearts at high preloads while their LVEDV are similar. The slope of LV EDPVR of cTnI-ND,Tnni3−/− hearts is flatter than that of WT hearts, consistent with enhanced myocardial relaxation that increases ventricular diastolic compliance. (B) The quantitative data confirmed similar LVEDV of cTnI-ND,Tnni3−/− and WT hearts at various preloads. The values are mean ± SEM. n = 5–6 mice in WT and 8–9 mice in cTnI-ND,Tnni3−/− groups. Statistical analysis was performed using two-way ANOVA with post-hoc method of Tukey’s test, and no significant difference was found.

cTnI-ND,Tnni3 −/− hearts showed unchanged LVEDV but flatter LV EDPVR in comparison with that of WT hearts. (A) The representative LV P-V loops of ex vivo working hearts at 5, 10, and 20 mmHg preloads illustrate the larger fraction shortening/stroke volume of cTnI-ND,Tnni3−/− hearts than that of WT hearts at high preloads while their LVEDV are similar. The slope of LV EDPVR of cTnI-ND,Tnni3−/− hearts is flatter than that of WT hearts, consistent with enhanced myocardial relaxation that increases ventricular diastolic compliance. (B) The quantitative data confirmed similar LVEDV of cTnI-ND,Tnni3−/− and WT hearts at various preloads. The values are mean ± SEM. n = 5–6 mice in WT and 8–9 mice in cTnI-ND,Tnni3−/− groups. Statistical analysis was performed using two-way ANOVA with post-hoc method of Tukey’s test, and no significant difference was found.

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