The PERK/E-Syt1 complex promotes lipid transport to mitochondria and the maintenance of mitochondrial functions in human cells. E-Syt1 is an ER anchored protein known to promote EPCSs expansion and to transport lipids at this site upon increase of intracellular Ca²⁺ concentration. The association of E-Syt1 to PM is mediated by the binding of C2E and C2C domains to PI(4,5)P₂ and negatively charged lipids enriched in the PM (4). In their work, Sassano et al. (3) showed that E-Syt1 is also important to mediate lipid transport at EMCSs. E-Syt1 is recruited at EMCSs by PERK, an ER kinase known to regulate mitochondria homeostasis during stress. E-Syt1 recruitment to EMCSs by PERK and its lipid transport activity are both required for efficient mitochondrial respiration and ATP production. GLs, glycerolipids; PI(4,5)P₂, phosphatidylinositol-(4,5)-bisphosphate; PS, phosphatidylserine.