The probenecid-induced cytosolic Ca2+elevation persists in the absence of extracellular calcium and under voltage-inactivated conditions. (A) Time course of probenecid-induced increase in fluo-4 fluorescence in three fibers bathed in the presence of calcium-containing Tyrode solution (circles) and in four fibers bathed in calcium-deprived Tyrode (triangles). (B) Probenecid-induced rise in rhod-2 fluorescence in five muscle fibers voltage-clamped at a holding voltage of −10 mV. Datasets were corrected, as in Fig. 6, by normalization with a linear function fitted to the data points before the application of the drug.
Figure 7.

The probenecid-induced cytosolic Ca 2+ elevation persists in the absence of extracellular calcium and under voltage-inactivated conditions. (A) Time course of probenecid-induced increase in fluo-4 fluorescence in three fibers bathed in the presence of calcium-containing Tyrode solution (circles) and in four fibers bathed in calcium-deprived Tyrode (triangles). (B) Probenecid-induced rise in rhod-2 fluorescence in five muscle fibers voltage-clamped at a holding voltage of −10 mV. Datasets were corrected, as in Fig. 6, by normalization with a linear function fitted to the data points before the application of the drug.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal