Distribution of HepG2 CC₂₀ values (from MMV) as function of NormRate ([Drug] = 10 µM; CC₂₀ values ≥ 80 μM have been set to 80 μM). (A) Scatter plot of HepG2 CC₂₀ vs. NormRate; green dots denote drugs with 50 µM ≤ CC₂₀; orange dots denote drugs with 10 µM ≤ CC₂₀ < 50 µM; red dots denote drugs with CC₂₀ < 10 µM. There is a weak correlation between CC₂₀ and NormRate (r² < 0.06); correlation line not shown. (B) Fractional distribution of NormRates for drugs with 50 µM ≤ CC₂₀ (top green graph), 10 µM ≤ CC₂₀ < 50 µM (middle orange graph), and CC₂₀ < 10 µM (bottom red graph); the curves at the top of each graph shows the cumulative distribution. Using ANOVA with Bonferroni correction for multiple comparisons there is a significant difference between the distributions for drugs with 50 µM ≤ CC₂₀ and drugs with 10 µM ≤ CC₂₀ < 50 µM (P = 4.8⋅10^–4) or drugs with CC₂₀ < 10 µM (P = 1.3⋅10^–4), as well as between drugs with 50 µM ≤ CC₂₀ and drugs with CC₂₀ < 50 µM (P = 6.8⋅10^–8). There is no difference between the distributions for drugs with 10 µM ≤ CC₂₀ < 50 µM and drugs with CC₂₀ < 10 µM (P = 1).