Trafficking-mediated disease of STING signaling mouse models. Trex1 ^−/− mouse is a model for AGS and ligand-mediated disease of STING signaling. Several recently described mouse models for trafficking-mediated diseases of STING signaling are also shown. COPA, COPA deficiency syndrome. BW, body weight. GoF, gain-of-function. LoF, loss-of-function. Red color indicate tissues affected in the mouse. Asterisk indicates that C9orf72^−/− mice do not develop ALS, although C9ORF72 is strongly associated with ALS in humans.