ASIC1a signaling in mesenteric endothelial cells. Left: In mesenteric endothelial cells, ASIC1a is activated by ACh. In the present study, we show this is likely due to the secondary activation via PKC, and not through endoplasmic reticulum (ER) store-depletion mechanisms involving STIM1 or AA. Right: Myoendothelial junction showing the presence of ASIC1a in the fenestrations of the IEL where it contributes to ACh-induced endothelium-dependent dilation through activation of IK_Ca/SK_Ca channels.