Figure 8.
p35 overexpression in neurons rescues neurodegeneration in babo knockdown animals. (A) Representative images of neuron cell bodies and axons within the wing in control and babo knockdown animals at 4 (top) and 28 (bottom) days of age with and without p35 expressed in neurons. Scale bar 5 µm. (B) Classification of axon integrity in control and babo knockdown animals at 28 d with and without p35. Pairwise Fisher Exact Probability Test (two-tailed, 2 × 3, n = 18 [control], 18 [control +P35], 12 [baboRNAi], 15 [baboRNAi +P35]). (C) Quantification of the number of VGlut+ neuron cell bodies in the wing from control and babo knockdown animals with and without p35. Mean ± 95% CI. Two-way ANOVA with Tukey’s multiple comparisons test (n = 36 [control], 36 [control +P35], 30 [baboRNAi], 33 [baboRNAi +P35]). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.

p35 overexpression in neurons rescues neurodegeneration in babo knockdown animals. (A) Representative images of neuron cell bodies and axons within the wing in control and babo knockdown animals at 4 (top) and 28 (bottom) days of age with and without p35 expressed in neurons. Scale bar 5 µm. (B) Classification of axon integrity in control and babo knockdown animals at 28 d with and without p35. Pairwise Fisher Exact Probability Test (two-tailed, 2 × 3, n = 18 [control], 18 [control +P35], 12 [baboRNAi], 15 [baboRNAi +P35]). (C) Quantification of the number of VGlut+ neuron cell bodies in the wing from control and babo knockdown animals with and without p35. Mean ± 95% CI. Two-way ANOVA with Tukey’s multiple comparisons test (n = 36 [control], 36 [control +P35], 30 [baboRNAi], 33 [baboRNAi +P35]). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.

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