Figure 2. Myosin heads move radially... | Rockefeller University Press

Figure 2.

$Myosin heads move radially away from the thick filament backbone. (a) Representative x-ray diffraction patterns from permeabilized porcine myocardium in different Ca2+ in the absence of force. (b) Change of equatorial intensity ratio (Δ I1,1/I1,0) at different Ca2+concentrations in the presence (red) and absence (black) of inhibitor (MYK-7660). (c) The radius of the average mass of myosin heads (Rm) at different Ca2+ concentrations in the presence (red) and absence (black) of inhibitor. Ca2+ shifts the distribution of myosin heads away from the thick filament backbone towards the thin filaments. Data are expressed as mean ± SEM (n = 12 in the control group and n = 11 in the inhibitor group).$

Myosin heads move radially away from the thick filament backbone. (a) Representative x-ray diffraction patterns from permeabilized porcine myocardium in different Ca²⁺ in the absence of force. (b) Change of equatorial intensity ratio (Δ I_1,1/I_1,0) at different Ca²⁺concentrations in the presence (red) and absence (black) of inhibitor (MYK-7660). (c) The radius of the average mass of myosin heads (R_m) at different Ca²⁺ concentrations in the presence (red) and absence (black) of inhibitor. Ca²⁺ shifts the distribution of myosin heads away from the thick filament backbone towards the thin filaments. Data are expressed as mean ± SEM (n = 12 in the control group and n = 11 in the inhibitor group).