Autophagy defective mutants have normal activation of the UPR ^mt in response to mitochondrial stress. qRT-PCR analysis of transcripts (n = 4 biologically independent samples) in wild-type (N2) or autophagy defect worm mutants fed with control or cco-1 RNAi. Error bars denote SEM. Statistical analysis was performed by ANOVA followed by Tukey post-hoc test (***P < 0.001).