TGF-β regulates the anatomic location of antigen-specific CD8 T cells activated in chronically infected mice. (A) CD45.1 WT or KO P14 cells were transferred separately into chronically infected CD45.2 recipient mice (>D45 p.i.). Representative confocal microscopy images of WT and KO P14 cells in the spleen on D20 after transfer. (B) Histocytometry analysis showing the distribution of total WT and KO P14 cells in different compartments of the spleen. (C) Histocytometry analysis showing the distribution of TCF-1− (left) and TCF-1+ (right) WT and KO P14 cells in different compartments of the spleen. The experiment was done with three mice per group. Two regions of 1.25 × 1.25 mm were analyzed per spleen, and the plots show the average. Student’s t test; *, P < 0.05.
Figure S4.

TGF-β regulates the anatomic location of antigen-specific CD8 T cells activated in chronically infected mice. (A) CD45.1 WT or KO P14 cells were transferred separately into chronically infected CD45.2 recipient mice (>D45 p.i.). Representative confocal microscopy images of WT and KO P14 cells in the spleen on D20 after transfer. (B) Histocytometry analysis showing the distribution of total WT and KO P14 cells in different compartments of the spleen. (C) Histocytometry analysis showing the distribution of TCF-1− (left) and TCF-1+ (right) WT and KO P14 cells in different compartments of the spleen. The experiment was done with three mice per group. Two regions of 1.25 × 1.25 mm were analyzed per spleen, and the plots show the average. Student’s t test; *, P < 0.05.

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