Figure 4.

Transcellular Cl reabsorption in the CD. Type A ICs secrete H+ while type B ICs secrete HCO3. Transport is powered by H+-ATPase on the apical and basolateral sides of the cell, respectively. When both are active, the net result is the reabsorption of Cl through apical pendrin and basolateral Cl channels. Transepithelial Na+ reabsorption by the principal cells (PC) can be balanced either by K+ secretion of Cl reabsorption.

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