Figure 4.
Transcellular Cl
−
reabsorption in the CD. Type A ICs secrete H+ while type B ICs secrete HCO3−. Transport is powered by H+-ATPase on the apical and basolateral sides of the cell, respectively. When both are active, the net result is the reabsorption of Cl− through apical pendrin and basolateral Cl− channels. Transepithelial Na+ reabsorption by the principal cells (PC) can be balanced either by K+ secretion of Cl− reabsorption.