HLA-DQ genotype distribution in CeD cases and at-risk controls
| Risk | HLA-DQ genotype | At-risk controls n = 117 (n)% | CeD n = 107 (n)% | OR (95% CI) | P value |
|---|---|---|---|---|---|
| High | 2.5/2.5 | 4 (3.4%) | 8 (7.5%) | 6.43 (2.57–16.07) | 7.44E-05 |
| 2.5/2.2 | 8 (6.8%) | 16 (15.0%) | |||
| Moderate | 2.5/X | 22 (18.8%) | 32 (29.9%) | 5.28 (2.59–10.76) | 2.14E-06 |
| 2.2/7.5 | 3 (2.6%) | 11 (10.3%) | |||
| 2.5/7.5 | 7 (6.0%) | 5 (4.7%) | |||
| 2.5/8.1 | 7 (6.0%) | 10 (9.3%) | |||
| 8.1/8.1 | 1 (<1%) | 5 (4.7%) | |||
| 2.2/8.1 | 2 (1.7%) | 6 (5.6%) | |||
| Low | 8.1/X | 10 (8.5%) | 6 (5.6%) | 1 | Reference |
| 7.5/8.1 | 1 (<1%) | 2 (1.9%) | |||
| 2.2/X | 21 (17.9%) | 3 (2.8%) | |||
| 7.5/X | 9 (7.7%) | 1 (<1%) | |||
| 2.2/2.2 | 2 (1.7%) | 2 (1.9%) | |||
| 7.5/7.5 | 2 (1.7%) | 0 (0%) | |||
| None | X/X | 18 (15.4%) | 0 (0%) | | |
| Risk | HLA-DQ genotype | At-risk controls | CeD | OR (95% CI) | P value |
|---|---|---|---|---|---|
| High | 2.5/2.5 | 4 (3.4%) | 8 (7.5%) | 6.43 (2.57–16.07) | 7.44E-05 |
| 2.5/2.2 | 8 (6.8%) | 16 (15.0%) | |||
| Moderate | 2.5/X | 22 (18.8%) | 32 (29.9%) | 5.28 (2.59–10.76) | 2.14E-06 |
| 2.2/7.5 | 3 (2.6%) | 11 (10.3%) | |||
| 2.5/7.5 | 7 (6.0%) | 5 (4.7%) | |||
| 2.5/8.1 | 7 (6.0%) | 10 (9.3%) | |||
| 8.1/8.1 | 1 (<1%) | 5 (4.7%) | |||
| 2.2/8.1 | 2 (1.7%) | 6 (5.6%) | |||
| Low | 8.1/X | 10 (8.5%) | 6 (5.6%) | 1 | Reference |
| 7.5/8.1 | 1 (<1%) | 2 (1.9%) | |||
| 2.2/X | 21 (17.9%) | 3 (2.8%) | |||
| 7.5/X | 9 (7.7%) | 1 (<1%) | |||
| 2.2/2.2 | 2 (1.7%) | 2 (1.9%) | |||
| 7.5/7.5 | 2 (1.7%) | 0 (0%) | |||
| None | X/X | 18 (15.4%) | 0 (0%) | | |
n, number. Statistical significance was determined by Fisher’s exact test.
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