Table 1.

Patient characteristics and sinusitis episode metrics by cohort

VariableTotalCVIDRTXControlCVID vs. controlRTX vs. controlCVID+RTX vs. control
N 3,297 79 224 2,994 ​ ​ ​ 
Age at end of follow-up (years) 63.0 [47.0, 73.0] 60.0 [47.0, 69.0] 64.0 [46.0, 74.0] 63.0 [46.0, 73.0] ​ ​ ​ 
Sex, male 1,317 (39.9%) 23 (29.1%) 99 (44.2%) 1,195 (39.9%) ​ ​ ​ 
Total episodes (simple counting) 4 [3, 5] 5 [3, 8] 4 [3, 7] 4 [3, 5] <0.001 <0.001 <0.001 
Total episodes (windowing) 3 [3, 5] 5 [3, 8] 4 [3, 6] 3 [3, 5] <0.001 0.131 <0.001 
Mean encounters per episode 1.0 [1.0, 1.2] 1.0 [1.0, 1.2] 1.2 [1.0, 1.4] 1.0 [1.0, 1.2] 0.513 <0.001 <0.001 
Longest episode (days) 7 [7, 20] 7 [7, 26] 13 [7, 28] 7 [7, 18] 0.081 <0.001 <0.001 
Episodes extended (%) 0.0 [0.0, 25.0] 0.0 [0.0, 19.4] 16.7 [0.0, 33.3] 0.0 [0.0, 25.0] 0.726 <0.001 <0.001 

Continuous variables: median [IQR]; categorical variables: n (%). Pairwise comparisons used Mann–Whitney U (continuous) or Fisher’s exact test (categorical). The CVID+RTX vs. control column pools both immunodeficient cohorts against matched controls. Simple counting treats each antibiotic encounter as a separate episode; windowing groups related encounters using a 28-day initial window with a 14-day extension.

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