Single channel conductance and rectification ratio for ELIC and other pLGICs from computational electrophysiology studies
| Structure | PDB | γo (pS) | γi (pS) | Rectification ratio |
|---|---|---|---|---|
| ELIC5 (cryo-EM) | 8TWV | 88 ± 5 | 23 ± 3 | 3.78 |
| ELIC5 (MD relaxed 1) | – | 153 ± 8 | 98 ± 5 | 1.57 |
| ELIC5 (MD relaxed 2) | – | 177 ± 7 | 102 ± 6 | 1.73 |
| Human α7 nAChR | 7KOX | 108 ± 12 | 10 ± 1 | 10.84 |
| Zebrafish α1 GlyR | 3JAE | 22 ± 3 | 215 ± 2 | 0.10 |
| Structure | PDB | Rectification ratio | ||
|---|---|---|---|---|
| ELIC5 (cryo-EM) | 88 ± 5 | 23 ± 3 | 3.78 | |
| ELIC5 (MD relaxed 1) | – | 153 ± 8 | 98 ± 5 | 1.57 |
| ELIC5 (MD relaxed 2) | – | 177 ± 7 | 102 ± 6 | 1.73 |
| Human | 108 ± 12 | 10 ± 1 | 10.84 | |
| Zebrafish | 22 ± 3 | 215 ± 2 | 0.10 |
γo is estimated using a linear fit of all data points from 0, +100, and +250 mV; γi is estimated using a linear fit of all data points from 0 to 100 and −250 mV. The error in the plot represents the standard error from the linear fitting.
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