Table 1. Purported open-channel... | Rockefeller University Press

Table 1.

Purported open-channel structures of pLGICs and their predicted conductance from computational electrophysiology studies

Channel	PDB^{^a}	Res. (Å)	Membrane mimetic	Stabilizing factors	Min. pore diameter (Å)	Computed conductance (pS)^{^b}
DeCLIC	6V4A	3.83	Micelle; DDM	—	10.2	—
ELIC5	8TWV	3.40	spNW15 nanodisc; POPC, POPE, POPG	—	6.6	—^{^c}
ELIC5	9NGC	2.80	Liposome; POPC, POPE, POPG	—	4.4	—
GLIC	3EAM	2.90	Micelle; DDM	—	5.0	—
GLIC	4HFI	2.40	Micelle; DDM	—	5.0	—
GLIC	5V6N	3.35	Micelle; DDM	C27S/K33C/I233A/N245C; DTT	5.0	18^{^d} (9) Gonzalez-Gutierrez et al. (2017)
GluCl	3RHW	3.30	Mixed Micelle; DDM, POPC, DPPC	Anti-GluCl Fab; Ivermectin	4.6	—
α1 GlyR	3JAE	3.90	Micelle; DDM	—	8.8	413^{^d} (80–88) Cerdan et al. (2018)
α1 GlyR	6UD3	3.50	MSP1E3D1 nanodisc; soy polar extract	Picrotoxin	6.5	20^{^e} (80–88) Kumar et al. (2020a)
α7 nAChR	7KOX	2.70	Saposin nanodisc; soy polar extract	PNU-120596	7.2	76^e (186) Zhuang et al. (2022)
sTeLIC	6FL9	2.30	Mixed Micelles; DDM, NDG	—	11	—
5-HT_3AR	6DG8	3.89	Micelle; C₁₂E₉	—	6.4	—
β3 GABA_AR	9FF0	3.40	MSP2N2 nanodisc; POPC, bovine brain extract	—	4.4	—

Channel	PDB^a	Res. (Å)	Membrane mimetic	Stabilizing factors	Min. pore diameter (Å)	Computed conductance (pS)^b
DeCLIC	6V4A	3.83	Micelle; DDM	—	10.2	—
ELIC5	8TWV	3.40	spNW15 nanodisc; POPC, POPE, POPG	—	6.6	—^c
ELIC5	9NGC	2.80	Liposome; POPC, POPE, POPG	—	4.4	—
GLIC	3EAM	2.90	Micelle; DDM	—	5.0	—
GLIC	4HFI	2.40	Micelle; DDM	—	5.0	—
GLIC	5V6N	3.35	Micelle; DDM	C27S/K33C/I233A/N245C; DTT	5.0	18^d (9) Gonzalez-Gutierrez et al. (2017)
GluCl	3RHW	3.30	Mixed Micelle; DDM, POPC, DPPC	Anti-GluCl Fab; Ivermectin	4.6	—
α1 GlyR	3JAE	3.90	Micelle; DDM	—	8.8	413^d (80–88) Cerdan et al. (2018)
α1 GlyR	6UD3	3.50	MSP1E3D1 nanodisc; soy polar extract	Picrotoxin	6.5	20^e (80–88) Kumar et al. (2020a)
α7 nAChR	7KOX	2.70	Saposin nanodisc; soy polar extract	PNU-120596	7.2	76e (186) Zhuang et al. (2022)
sTeLIC	6FL9	2.30	Mixed Micelles; DDM, NDG	—	11	—
5-HT_3AR	6DG8	3.89	Micelle; C₁₂E₉	—	6.4	—
β3 GABA_AR	9FF0	3.40	MSP2N2 nanodisc; POPC, bovine brain extract	—	4.4	—

References for PDBs are 6V4A, Hu et al. (2020); 8TWV, Dalal et al. (2024); 9NGC, Dalal et al. (2025); 3EAM, Bocquet et al. (2009); 4HFI, Sauguet et al. (2013); 5V6N, Gonzalez-Gutierrez et al. (2017); 3RHW, Hibbs and Gouaux (2011); 3JAE, Du et al. (2015); 6UD3, Kumar et al. (2020a); 7KOX, Noviello et al. (2021); 6FL9, Hu et al. (2018); 6DG8, Basak et al. (2018); 9FF0, Mihaylov et al. (2025 , Preprint).

Value in parentheses is the experimental single channel conductance.

Values are from this study.

These studies removed the ECD for computational electrophysiology.

ICD was unresolved for this model and not included in computational electrophysiology studies.

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