NGS-based TCRγ clones in P1 pre-JAK inhibition (2017) vs. under JAK inhibition (2024)
| TRGV gene | TRGJ gene | CDR3γ amino acid code | CDR3γ nucleotide code | Frequency (2017) | Frequency (2024) |
|---|---|---|---|---|---|
| TRGV9 | TRGJP | ALWEVRELGKKIKV | 5′-GCCTTGTGGGAGGTGCGGGAGTTGGGCAAAAAAATCAAGGTA-3′ | 0.067 | 0.133 |
| TRGV9 | TRGJ1 | ARPIYRWET | 5′-GCCCGCCCCATATATCGGTGGGAAACTC-3′ | 0.030 | 0.017 |
| TRGV10 | TRGJ1 | AAWVPKGET | 5′-GCTGCGTGGGTCCCAAAGGGAGAAACTC-3′ | 0.023 | 0.014 |
| TRGV9 | TRGJ1 | ASGVR*L | 5′-GCCTCGGGAGTGCGTTGACTC-3′ | 0.015 | <0.002 |
| TRGV10 | TRGJ1 | AAWDYWET | 5′-GCTGCGTGGGATTACTGGGAAACTC-3′ | 0.014 | 0.007 |
| TRGV10 | TRGJ1 | AAWDLRN | 5′-GCTGCGTGGGATTTAAGAAACTC-3′ | 0.013 | <0.002 |
| TRGV10 | TRGJ1 | AAWGELL*ET | 5′-GCTGCGTGGGGAGAATTATTATAAGAAACTC-3′ | 0.013 | 0.047 |
| TRGV9 | TRGJ1 | ALWEVEET | 5′-GCCTTGTGGGAGGTGGAAGAAACTC-3′ | 0.009 | <0.002 |
| TRGV10 | TRGJ1 | AAWET | 5′-GCTGCGTGGGAAACTC-3′ | 0.008 | <0.002 |
| TRGV9 | TRGJ1 | ALWEERN | 5′-GCCTTGTGGGAGGAAAGAAACTC-3′ | 0.008 | <0.002 |
| TRGV9 | TRGJ1 | ALWEARWKL | 5′-GCCTTGTGGGAGGCGAGGTGGAAACTC-3′ | 0.008 | <0.002 |
| TRGV9 | TRGJ1 | ALWEVPPREL | 5′-GCCTTGTGGGAGGTCCCCCCTAGGGAACTC-3′ | 0.008 | <0.002 |
| TRGV9 | TRGJ1 | ALWTQEET | 5′-GCCTTGTGGACGCAGGAAGAAACTC-3′ | 0.006 | <0.002 |
| TRGV9 | TRGJ1 | ALWEITILRS | 5′-GCCTTGTGGGAGATTACGATTTTAAGAAGCTC-3′ | 0.006 | <0.002 |
| TRGV9 | TRGJ1 | ALWEVVIIRN | 5′-GCCTTGTGGGAGGTGGTTATTATAAGAAACTC-3′ | 0.006 | <0.002 |
| TRGV9 | TRGJ1 | ALWEVRL*ET | 5′-GCCTTGTGGGAGGTGCGGGGTTATAAGAAACTC-3′ | 0.006 | <0.002 |
| TRGV9 | TRGJ1 | ALWEVL*ET | 5′-GCCTTGTGGGAGGTATTATAAGAAACTC-3′ | 0.006 | <0.002 |
| TRGV9 | TRGJP | ALWEVQELGKKIKV | 5′-GCCTTGTGGGAGGTGCAAGAGTTGGGCAAAAAAATCAAGGTA-3′ | 0.005 | <0.002 |
| TRGV9 | TRGJ1 | ALWDTIRN | 5′-GCCTTGTGGGATACTATAAGAAACTC-3′ | 0.005 | <0.002 |
| TRGV10 | TRGJ1 | AAWDPGN | 5′-GCTGCGTGGGATCCGGGAAACTC-3′ | 0.004 | <0.002 |
| TRGV9 | TRGJ1 | ALWEVRET | 5′-GCCTTGTGGGAGGTGCGGGAAACTC-3′ | 0.004 | <0.002 |
| TRGV9 | TRGJ1 | ALWEVKAIRN | 5′-GCCTTGTGGGAGGTGAAAGCCATAAGAAACTC-3′ | 0.004 | <0.002 |
| TRGV9 | TRGJ1 | ALWEVGYKKL | 5′-GCCTTGTGGGAGGTGGGTTATAAGAAACTC-3′ | 0.004 | <0.002 |
| TRGV10 | TRGJ1 | AAWDYKKL | 5′-GCTGCGTGGGATTATAAGAAACTC-3′ | 0.003 | <0.002 |
| TRGV4 | TRGJ1 | ATLGWT | 5′-GCCACCCTCGGTTGGACTC-3′ | 0.003 | <0.002 |
| CDR3γ amino acid code | CDR3γ nucleotide code | Frequency (2017) | Frequency (2024) | ||
|---|---|---|---|---|---|
| ALWEVRELGKKIKV | 5′-GCCTTGTGGGAGGTGCGGGAGTTGGGCAAAAAAATCAAGGTA-3′ | 0.067 | 0.133 | ||
| ARPIYRWET | 5′-GCCCGCCCCATATATCGGTGGGAAACTC-3′ | 0.030 | 0.017 | ||
| AAWVPKGET | 5′-GCTGCGTGGGTCCCAAAGGGAGAAACTC-3′ | 0.023 | 0.014 | ||
| ASGVR*L | 5′-GCCTCGGGAGTGCGTTGACTC-3′ | 0.015 | <0.002 | ||
| AAWDYWET | 5′-GCTGCGTGGGATTACTGGGAAACTC-3′ | 0.014 | 0.007 | ||
| AAWDLRN | 5′-GCTGCGTGGGATTTAAGAAACTC-3′ | 0.013 | <0.002 | ||
| AAWGELL*ET | 5′-GCTGCGTGGGGAGAATTATTATAAGAAACTC-3′ | 0.013 | 0.047 | ||
| ALWEVEET | 5′-GCCTTGTGGGAGGTGGAAGAAACTC-3′ | 0.009 | <0.002 | ||
| AAWET | 5′-GCTGCGTGGGAAACTC-3′ | 0.008 | <0.002 | ||
| ALWEERN | 5′-GCCTTGTGGGAGGAAAGAAACTC-3′ | 0.008 | <0.002 | ||
| ALWEARWKL | 5′-GCCTTGTGGGAGGCGAGGTGGAAACTC-3′ | 0.008 | <0.002 | ||
| ALWEVPPREL | 5′-GCCTTGTGGGAGGTCCCCCCTAGGGAACTC-3′ | 0.008 | <0.002 | ||
| ALWTQEET | 5′-GCCTTGTGGACGCAGGAAGAAACTC-3′ | 0.006 | <0.002 | ||
| ALWEITILRS | 5′-GCCTTGTGGGAGATTACGATTTTAAGAAGCTC-3′ | 0.006 | <0.002 | ||
| ALWEVVIIRN | 5′-GCCTTGTGGGAGGTGGTTATTATAAGAAACTC-3′ | 0.006 | <0.002 | ||
| ALWEVRL*ET | 5′-GCCTTGTGGGAGGTGCGGGGTTATAAGAAACTC-3′ | 0.006 | <0.002 | ||
| ALWEVL*ET | 5′-GCCTTGTGGGAGGTATTATAAGAAACTC-3′ | 0.006 | <0.002 | ||
| ALWEVQELGKKIKV | 5′-GCCTTGTGGGAGGTGCAAGAGTTGGGCAAAAAAATCAAGGTA-3′ | 0.005 | <0.002 | ||
| ALWDTIRN | 5′-GCCTTGTGGGATACTATAAGAAACTC-3′ | 0.005 | <0.002 | ||
| AAWDPGN | 5′-GCTGCGTGGGATCCGGGAAACTC-3′ | 0.004 | <0.002 | ||
| ALWEVRET | 5′-GCCTTGTGGGAGGTGCGGGAAACTC-3′ | 0.004 | <0.002 | ||
| ALWEVKAIRN | 5′-GCCTTGTGGGAGGTGAAAGCCATAAGAAACTC-3′ | 0.004 | <0.002 | ||
| ALWEVGYKKL | 5′-GCCTTGTGGGAGGTGGGTTATAAGAAACTC-3′ | 0.004 | <0.002 | ||
| AAWDYKKL | 5′-GCTGCGTGGGATTATAAGAAACTC-3′ | 0.003 | <0.002 | ||
| ATLGWT | 5′-GCCACCCTCGGTTGGACTC-3′ | 0.003 | <0.002 |
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