Table 2. Prevalence of... | Rockefeller University Press

Table 2.

Prevalence of methionine-for-leucine substitution in TTX-sensitive v.g. Na channels of the hearts of hibernators

Common name	Technical name	NQATX.., X = ?					Hibernator?
Common name	Technical name	SCN1A Nav1.1A	SCN2A Nav1.2A	SCN3A Nav1.3A	SCN8A Nav1.6A	SCN4A Nav1.4A	Hibernator?
13-Lined ground squirrel	Ictidomys tridecemlineatus	M	M	______	L	L	Yes
Arctic ground squirrel	Urocitellus parryii	M	M	L	L	L	Yes
Yellow-bellied marmot	Marmota flaviventris	M	M	______	L	L	Yes
Woodchuck or groundhog	Marmota monax	M	L	M	L	L	Yes
European marmot	Marmota marmota	M	L	______	L	L	Yes
Golden hamster	Mesocricetus auratus	L	L	______	L	L	Yes
European hedgehog	Erinaceus europeus	M	M	L	L	L	Yes
Little brown bat	Myotis lucifugus or Myotis	M	M	L	L	M	Yes
Big brown bat	Eptesicus fuscus	M	M	______	L	M	Yes
Beaver	Castor canadensis	_____	L	L	L	L	No
Guinea pig	Cavia porcellus	L	L	______	L	L	No
Deermouse	Peromyscus maniculatis	L	L	______	L	L	No
Norway rat	Rattus norvegicus	L	L		L	L	No
E gray squirrel	Sciurus carolinensis	L	L	______	L	L	No
Rabbit	Oryctolagus cuniculus	______	L	______	L	L	No
Dog	Canis lupus familiaris	L	L	______	L	L	No
Shrew	Sorex araneus	L	L	______	L	L	No
Elephant	Loxodonta africanus	L	L	______	L	L	No
Horse	Equus caballus	L	L	L	L	L	No
Human	Homo sapiens	L	L	______	L	L	No

Common name	Technical name	NQATX.., X = ?					Hibernator?
Common name	Technical name	SCN1ANav1.1A	SCN2ANav1.2A	SCN3ANav1.3A	SCN8ANav1.6A	SCN4ANav1.4A	Hibernator?
13-Lined ground squirrel	Ictidomys tridecemlineatus	M	M	______	L	L	Yes
Arctic ground squirrel	Urocitellus parryii	M	M	L	L	L	Yes
Yellow-bellied marmot	Marmota flaviventris	M	M	______	L	L	Yes
Woodchuck or groundhog	Marmota monax	M	L	M	L	L	Yes
European marmot	Marmota marmota	M	L	______	L	L	Yes
Golden hamster	Mesocricetus auratus	L	L	______	L	L	Yes
European hedgehog	Erinaceus europeus	M	M	L	L	L	Yes
Little brown bat	Myotis lucifugus or Myotis	M	M	L	L	M	Yes
Big brown bat	Eptesicus fuscus	M	M	______	L	M	Yes
Beaver	Castor canadensis	_____	L	L	L	L	No
Guinea pig	Cavia porcellus	L	L	______	L	L	No
Deermouse	Peromyscus maniculatis	L	L	______	L	L	No
Norway rat	Rattus norvegicus	L	L		L	L	No
E gray squirrel	Sciurus carolinensis	L	L	______	L	L	No
Rabbit	Oryctolagus cuniculus	______	L	______	L	L	No
Dog	Canis lupus familiaris	L	L	______	L	L	No
Shrew	Sorex araneus	L	L	______	L	L	No
Elephant	Loxodonta africanus	L	L	______	L	L	No
Horse	Equus caballus	L	L	L	L	L	No
Human	Homo sapiens	L	L	______	L	L	No

The segment in which an M-for-L mutation is found is in the sixth transmembrane segment of domain one (DIS6) and begins NQAT in most Nav1s. (In Nav1.4, glutamate replaces glutamine, thus NEAT.) Criteria for the selection of hibernators are provided in Materials and methods. Briefly, nonhibernators resist lowering of body temperature below 30°C in a cold environment by increasing heat production and insulation. Hibernators listed in the table in low ambient temperature and under appropriate circumstances, specific to the species, allow or even promote a decrease in core temperature to below 10°C and to as low as 0°C and regulate temperature and respiration at that low temperature for days or weeks. Dashed lines indicate that no sequence was available in the NCBI database. In the headings of each column, gene names are shown above protein identities.

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