Table 1. Multivariable model of OS for... | Rockefeller University Press

Table 1.

Multivariable model of OS for non-MSD transplants

Category	Variable	HR (95%CI)	P value	Overall P value
Race/Ethnicity	NH White	ref		<0.001
	Hispanic	1.32 (0.93, 1.88)	0.12
	Asian/PI	1.82 (1.00, 3.30)	0.05
	Black	2.47 (1.64, 3.71)	<0.001
	Native American	0.74 (0.35, 1.56)	0.43
	Unknown	1.95 (1.19, 3.08)	0.008
Age at treatment	<3.5 mo	ref		0.002
Age at treatment	>3.5 mo	1.92 (1.27, 2.91)	0.002
Donor Type^{^a}	HLA-mismatched relative	ref		0.26
	HLA-matched other relative	0.47 (0.20, 1.07)	0.08
	HLA-matched unrelated	1.17 (0.69, 1.98)	0.55
	HLA-mismatched unrelated	1.26 (0.85, 1.88)	0.25
	Unrelated/unknown matching	0.80 (0.25, 2.58)	0.71
Infection status	No infection	ref		<0.001
	Active infection	2.11 (1.35, 3.29)	0.001
	Missing	0.34 (0.05, 2.56)	0.30
	Resolved infection	1.14 (0.69, 1.88)	0.61
	Unknown infection status	1.78 (1.02, 3.11)	0.03
Genotype	IL2RG/JAK3	ref		<0.001
	ADA	2.33 (1.29, 4.18)	0.005
	DCLRE1C	4.04 (2.09, 7.81)	<0.001
	IL7R	1.27 (0.69, 2.33)	0.540
	Novel/missing	2.34 (1.65, 3.31)	<0.001
	Other/unknown	3.35 (1.65, 7.23)	0.002
	RAG1/2	2.18 (1.28, 3.73)	0.004
Decade of treatment	1980–1990	ref		0.02
	1990–2000	1.33 (0.89, 2.04)	0.18
	2000–2010	1.16 (0.76, 1.85)	0.51
	2010–2020	0.61 (0.33, 1.08)	0.11

Category	Variable	HR (95%CI)	P value	Overall P value
Race/Ethnicity	NH White	ref		<0.001
	Hispanic	1.32 (0.93, 1.88)	0.12
	Asian/PI	1.82 (1.00, 3.30)	0.05
	Black	2.47 (1.64, 3.71)	<0.001
	Native American	0.74 (0.35, 1.56)	0.43
	Unknown	1.95 (1.19, 3.08)	0.008
Age at treatment	<3.5 mo	ref		0.002
Age at treatment	>3.5 mo	1.92 (1.27, 2.91)	0.002
Donor Type^a	HLA-mismatched relative	ref		0.26
	HLA-matched other relative	0.47 (0.20, 1.07)	0.08
	HLA-matched unrelated	1.17 (0.69, 1.98)	0.55
	HLA-mismatched unrelated	1.26 (0.85, 1.88)	0.25
	Unrelated/unknown matching	0.80 (0.25, 2.58)	0.71
Infection status	No infection	ref		<0.001
	Active infection	2.11 (1.35, 3.29)	0.001
	Missing	0.34 (0.05, 2.56)	0.30
	Resolved infection	1.14 (0.69, 1.88)	0.61
	Unknown infection status	1.78 (1.02, 3.11)	0.03
Genotype	IL2RG/JAK3	ref		<0.001
	ADA	2.33 (1.29, 4.18)	0.005
	DCLRE1C	4.04 (2.09, 7.81)	<0.001
	IL7R	1.27 (0.69, 2.33)	0.540
	Novel/missing	2.34 (1.65, 3.31)	<0.001
	Other/unknown	3.35 (1.65, 7.23)	0.002
	RAG1/2	2.18 (1.28, 3.73)	0.004
Decade of treatment	1980–1990	ref		0.02
	1990–2000	1.33 (0.89, 2.04)	0.18
	2000–2010	1.16 (0.76, 1.85)	0.51
	2010–2020	0.61 (0.33, 1.08)	0.11

HLA, human leukocyte antigen; Ref, reference group. Bold values indicate P values that met the threshold for statistical significance.

In initial model building where MSD transplants were included, donor type was statistically significant; thus, donor type was retained in the final model (despite the subsequent exclusion of patients who received a transplant from an MSD) based on the previous statistical significance and the effect detected of HLA-matched other relative donor type.

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