Functional roles of KATP complex isoforms across muscle types
| | Cardiac muscle | Smooth muscle | Skeletal muscle (e.g., fast twitch) |
|---|---|---|---|
| Kir6.2/SUR2A | AP duration (ventricular), during ischemia (Zhu et al., 2011) | Not shown | Fatigue Brake (SUR2) (Scala et al., 2026) |
| Kir 6.1/SUR2B | Not shown | Basal vascular tone and blood pressure (Aziz et al, 2014; Dart, 2014) | Not shown |
| Kir 6.1 | AP fine-tuning, SUR isoform unknown (Brennan et al., 2024) Heart rate modulation via SAN, SUR isoform unknown (Aziz et al., 2018) | Combined with SUR1? Possible (Teramoto, 2006) | Not shown |
| | Cardiac muscle | Smooth muscle | Skeletal muscle (e.g., fast twitch) |
|---|---|---|---|
| Kir6.2/SUR2A | AP duration (ventricular), during ischemia | Not shown | Fatigue Brake (SUR2) |
| Kir 6.1/SUR2B | Not shown | Basal vascular tone and blood pressure | Not shown |
| Kir 6.1 | AP fine-tuning, SUR isoform unknown | Combined with SUR1? Possible | Not shown |
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