Antimicrobial strategies for P. aeruginosa eradication in STAT3-HIES
| Regimena | Duration | Notes |
|---|---|---|
| Inhaled tobramycin | 4 wk | First-line if inhalation feasible |
| Ciprofloxacin orally 3 wk + inhaled colistin 3 mo | 3 mo | Combination superior to systemic alone |
| Intravenous antipseudomonal β-lactam + aminoglycoside | 14 days | Inhalation not feasible |
| Regimen | Duration | Notes |
|---|---|---|
| Inhaled tobramycin | 4 wk | First-line if inhalation feasible |
| Ciprofloxacin orally 3 wk + inhaled colistin 3 mo | 3 mo | Combination superior to systemic alone |
| Intravenous antipseudomonal β-lactam + aminoglycoside | 14 days | Inhalation not feasible |
Final choice of drugs, doses, and durations should follow local cystic fibrosis/bronchiectasis protocols and should be individualized to age, weight, renal/hepatic function, and susceptibility testing.