Table 1. Summary of the mouse models... | Rockefeller University Press

Table 1.

Summary of the mouse models used in this study and their associated phenotypes

Name	Genotype	N	Histological phenotype	Mets	NEPC
NPp53-SB(−)	Nkx3.1^CreERT2/+; Pten^flox/flox; Trp53^flox/flox; R26^{LSL-SB11/LSL-SB11}	31	Poorly differentiated adenocarcinoma with sarcomatoid features	7/31 (22%)	1/31 (3%)
NPp53-SB(+)	Nkx3.1^CreERT2/+; Pten^flox/flox; Trp53^flox/flox; R26^{LSL-SB11/LSL-SB11}; T2/Onc2	93	Poorly differentiated adenocarcinoma with sarcomatoid features and neuroendocrine differentiation	57/93 (61%)	32/84 (38%)
NP-SB(−)	Nkx3.1^CreERT2/+; Pten^flox/flox; R26^{LSL-SB11/LSL-SB11}	12	High-grade PIN, well-differentiated adenocarcinoma	0/12 (0%)	0/12 (0%)
NP-SB(+)	Nkx3.1^CreERT2/+; Pten^flox/flox; R26^{LSL-SB11/LSL-SB11}; T2/Onc2	18	High-grade PIN, well-differentiated adenocarcinoma	0/18 (0%)	0/18 (0%)

Name	Genotype	N	Histological phenotype	Mets	NEPC
NPp53-SB(−)	Nkx3.1^CreERT2/+; Pten^flox/flox; Trp53^flox/flox; R26^{LSL-SB11/LSL-SB11}	31	Poorly differentiated adenocarcinoma with sarcomatoid features	7/31 (22%)	1/31 (3%)
NPp53-SB(+)	Nkx3.1^CreERT2/+; Pten^flox/flox; Trp53^flox/flox; R26^{LSL-SB11/LSL-SB11}; T2/Onc2	93	Poorly differentiated adenocarcinoma with sarcomatoid features and neuroendocrine differentiation	57/93 (61%)	32/84 (38%)
NP-SB(−)	Nkx3.1^CreERT2/+; Pten^flox/flox; R26^{LSL-SB11/LSL-SB11}	12	High-grade PIN, well-differentiated adenocarcinoma	0/12 (0%)	0/12 (0%)
NP-SB(+)	Nkx3.1^CreERT2/+; Pten^flox/flox; R26^{LSL-SB11/LSL-SB11}; T2/Onc2	18	High-grade PIN, well-differentiated adenocarcinoma	0/18 (0%)	0/18 (0%)

Mets, metastasis; NEPC, neuroendocrine prostate cancer; PIN, prostatic intraepithelial neoplasia.