Table 4. Properties of onset and... | Rockefeller University Press

Table 4.

Properties of onset and recovery from inactivation for FGF14A mutants and isoforms

Constructs	Recovery from inactivation at −80 mV
Constructs	τ_f (ms)	P value	τ_s (ms)	P value	A_s	P value	N
Na_V1.2	8.7 ± 2.3						22 (16)
+FGF14A	5.4 ± 1.8	<0.0001 ^WT	592.9 ± 111.5		0.60 ± 0.06		31 (18)
+FGF14A_LI/AA	6.4 ± 0.9	0.11 ^WT >0.99 ^14A					6 (2)
+FGF14A_2Q	6.3 ± 1.6	0.12 ^WT >0.99 ^14A	221.8 ± 12.7	<0.0001 ^14A	0.58 ± 0.05	0.35 ^14A	5 (2)
+FGF14A_5Q	4.6 ± 0.3	0.008 ^WT >0.99 ^14A					3 (2)
+FGF14A_ΔNT	5.5 ± 0.6	0.005 ^WT >0.99 ^14A					6 (3)
+FGF14B	7.2 ± 2.0	0.27 ^WT 0.05 ^14A					13 (5)

Constructs	Recovery from inactivation at −80 mV
Constructs	τ_f (ms)	P value	τ_s (ms)	P value	A_s	P value	N
Na_V1.2	8.7 ± 2.3						22 (16)
+FGF14A	5.4 ± 1.8	<0.0001 ^WT	592.9 ± 111.5		0.60 ± 0.06		31 (18)
+FGF14A_LI/AA	6.4 ± 0.9	0.11 ^WT>0.99 ^14A					6 (2)
+FGF14A_2Q	6.3 ± 1.6	0.12 ^WT>0.99 ^14A	221.8 ± 12.7	<0.0001 ^14A	0.58 ± 0.05	0.35 ^14A	5 (2)
+FGF14A_5Q	4.6 ± 0.3	0.008 ^WT>0.99 ^14A					3 (2)
+FGF14A_ΔNT	5.5 ± 0.6	0.005 ^WT>0.99 ^14A					6 (3)
+FGF14B	7.2 ± 2.0	0.27 ^WT0.05 ^14A					13 (5)

Statistical analyses were performed using one-way ANOVA, followed by Bonferroni’s multiple comparisons test. Statistical analyses of parameters from slow component between FGF14A and FGF14A_2Q were performed using unpaired t test with Welch’s correction.

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