Table 2. Properties of recovery from... | Rockefeller University Press

Table 2.

Properties of recovery from inactivation for Na_V1.2 + FGF-A isoforms

Construct	Recovery from inactivation at −80 mV
Construct	τ_f (ms)	P value	A_f	P value	τ_s (ms)	P value	A_s	P value	N
Na_V1.2	8.7 ± 2.3	<0.0001 ^14A 0.002 ^13A 0.0004 ^12A 0.87 ^11A	0.99 ± 0.02	<0.0001 ^14A <0.0001 ^13A <0.0001 ^12A <0.0001 ^11A					22 (16)
+FGF14A	5.4 ± 1.8	0.46 ^13A 0.99 ^12A 0.007 ^11A	0.40 ± 0.06	<0.0001 ^13A <0.0001 ^12A <0.0001 ^11A	592.9 ± 111.5	<0.0001 ^13A 0.05 ^12A < 0.0001 ^11A	0.60 ± 0.06	<0.0001 ^13A <0.0001 ^12A <0.0001 ^11A	31 (18)
+FGF13A	6.3 ± 1.7	0.50 ^12A 0.21 ^11A	0.54 ± 0.06	<0.0001 ^12A 0.99 ^11A	2017.6 ± 324.0	<0.0001 ^12A <0.0001 ^11A	0.45 ± 0.06	<0.0001 ^12A 0.99 ^11A	25 (16)
+FGF12A	5.0 ± 2.6	0.02 ^11A	0.70 ± 0.04	<0.0001 ^11A	497.2 ± 97.7	<0.0001^11A	0.29 ± 0.04	<0.0001 ^11A	8 (2)
+FGF11A	7.9 ± 2.7		0.55 ± 0.05		173.1 ± 19.7		0.44 ± 0.05		11 (7)

Construct	Recovery from inactivation at −80 mV
Construct	τ_f (ms)	P value	A_f	P value	τ_s (ms)	P value	A_s	P value	N
Na_V1.2	8.7 ± 2.3	<0.0001 ^14A0.002 ^13A0.0004 ^12A0.87 ^11A	0.99 ± 0.02	<0.0001 ^14A<0.0001 ^13A<0.0001 ^12A<0.0001 ^11A					22 (16)
+FGF14A	5.4 ± 1.8	0.46 ^13A0.99 ^12A0.007 ^11A	0.40 ± 0.06	<0.0001 ^13A<0.0001 ^12A<0.0001 ^11A	592.9 ± 111.5	<0.0001 ^13A0.05 ^12A< 0.0001 ^11A	0.60 ± 0.06	<0.0001 ^13A<0.0001 ^12A<0.0001 ^11A	31 (18)
+FGF13A	6.3 ± 1.7	0.50 ^12A0.21 ^11A	0.54 ± 0.06	<0.0001 ^12A0.99 ^11A	2017.6 ± 324.0	<0.0001 ^12A<0.0001 ^11A	0.45 ± 0.06	<0.0001 ^12A0.99 ^11A	25 (16)
+FGF12A	5.0 ± 2.6	0.02 ^11A	0.70 ± 0.04	<0.0001 ^11A	497.2 ± 97.7	<0.0001^11A	0.29 ± 0.04	<0.0001 ^11A	8 (2)
+FGF11A	7.9 ± 2.7		0.55 ± 0.05		173.1 ± 19.7		0.44 ± 0.05		11 (7)

In all tables, parameter values are means ± SD, while N = number of biological replicates (cells) with number of transfections given in parentheses. Statistical analyses were performed using one-way ANOVA, followed by Tukey’s multiple comparisons test (for τ_slow parameter, a lognormal distribution was used to satisfy ANOVA assumptions of normality and homogeneity of variance). In all tables, ^14A, ^12A, ^13A, and ^11A represent paired comparisons between WT+FGF14A, WT+FGF12A, WT+FGF13A, or WT+FGF11A, respectively, with the corresponding construct in the first column.

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