Table 1. Variant residues in human rDNA... | Rockefeller University Press

Table 1.

Variant residues in human rDNA conserved between individuals

rRNA	Residue	Ref	SNV	% of individuals with SNV	Average SNV frequency	Location	Sequence in chrUN_GL000220v1
18S	699	C	G	60	0.004	Disordered
18S	1,597	C	G	67	0.004	Head/h41
18S	1,615	T	C	73	0.005	Head/h42
28S	60	G	A	100	0.380	j11/12
28S	628	C	G	73	0.009	Disordered
28S	761	G	C	60	0.006	Disordered
28S	762	C	G	93	0.013	Disordered
28S	812	G	C	83	0.011	Disordered
28S	862	C	T	83	0.021	Disordered
28S	865	C	T	77	0.060	Disordered
28S	868	T	C	97	0.069	Disordered
28S	871	C	T	77	0.025	Disordered
28S	874	C	T	67	0.009	Disordered
28S	879	G	T	73	0.107	Disordered
28S	883	C	G	80	0.085	Disordered
28S	2,176	G	T	100	0.097	Disordered
28S	2,189	C	T	100	0.039	Disordered	T
28S	2,194	G	C	93	0.017	Disordered	C
28S	2,195	C	G	67	0.009	Disordered	G
28S	3,040	A	G	100	0.300	Disordered	C
28S	3,338	A	C	97	0.016	Disordered	C
28S	3,349	A	G	67	0.067	Disordered	C
28S	3,455	G	C	87	0.010	Disordered	C
28S	3,513	G	A	100	0.391	Disordered
28S	4,804	G	C	80	0.008	Disordered	C
28S	4,805	C	G	60	0.007	Disordered
28S	4,817	A	G	80	0.082	Disordered	C
28S	4,913	C	T	100	0.180	ES39B	G

rRNA	Residue	Ref	SNV	% of individuals with SNV	Average SNV frequency	Location	Sequence in chrUN_GL000220v1
18S	699	C	G	60	0.004	Disordered
18S	1,597	C	G	67	0.004	Head/h41
18S	1,615	T	C	73	0.005	Head/h42
28S	60	G	A	100	0.380	j11/12
28S	628	C	G	73	0.009	Disordered
28S	761	G	C	60	0.006	Disordered
28S	762	C	G	93	0.013	Disordered
28S	812	G	C	83	0.011	Disordered
28S	862	C	T	83	0.021	Disordered
28S	865	C	T	77	0.060	Disordered
28S	868	T	C	97	0.069	Disordered
28S	871	C	T	77	0.025	Disordered
28S	874	C	T	67	0.009	Disordered
28S	879	G	T	73	0.107	Disordered
28S	883	C	G	80	0.085	Disordered
28S	2,176	G	T	100	0.097	Disordered
28S	2,189	C	T	100	0.039	Disordered	T
28S	2,194	G	C	93	0.017	Disordered	C
28S	2,195	C	G	67	0.009	Disordered	G
28S	3,040	A	G	100	0.300	Disordered	C
28S	3,338	A	C	97	0.016	Disordered	C
28S	3,349	A	G	67	0.067	Disordered	C
28S	3,455	G	C	87	0.010	Disordered	C
28S	3,513	G	A	100	0.391	Disordered
28S	4,804	G	C	80	0.008	Disordered	C
28S	4,805	C	G	60	0.007	Disordered
28S	4,817	A	G	80	0.082	Disordered	C
28S	4,913	C	T	100	0.180	ES39B	G

Data are reanalyzed from Rothschild et al. (2024). A total of 185 SNV are observed and this Table contains the 28 SNV conserved in at least 60% of the 30 individuals from the 1,000 genome project (Byrska-Bishop et al., 2022) analyzed by Rothschild et al. (2024). Note that the rDNA numbering in Ref (Rothschild et al., 2024) starts with “0” and is thus shifted by one nucleotide, which is corrected here. If the residue in the chrUN_GL000220v1 reference sequence differs from the reported reference sequence, it is notated in the last column.

ES39B: extension segment 39B; h41: helix 41; j11/12: junction between helices 11 and 12; Ref: Reference; SSU: small (ribosomal) subunit. Residues in bold are not disordered and discussed in the text.

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