Table 1. Hematological and immunological... | Rockefeller University Press

Table 1.

Hematological and immunological features of the patient

		Patient		Reference values
Age at evaluation (years)	7	12	14
Serum Ig levels
IgG* (g/l)	5.8	6.24	11.43	6.98–15.6
IgA (g/l)	0.89	1.35	1.46	0.53–2.9
IgM (g/l)	0.52	0.67	0.72	0.31–1.62
Blood parameters
Hemoglobin (×10⁹/liter)		14.2	14.9	13–17
MCV (fl)		NA	88.4	78–96
Leukocytes (×10⁹/liter)		7.15	7.58	4.5–13
Platelets (×10⁹/liter)		315	291	150–450
Monocytes (×10⁹/liter)		NA	0.75	0.3–1
Neutrophils (×10⁹/liter)		3.97	4.28	2–8
T lymphocytes
CD3⁺(/μl)		2,534	1,729	1,000–2,200
CD3⁺CD4⁺(/μl)		1,404	922	530–1,300
Naive CD4⁺/CD45RA⁺ (%)		71	66.4	58–70
Memory CD4⁺/CD45RO⁺ (%)		29	33.6	34–67
CD4⁺/CD31⁺CD45RA⁺ (%)		49	49.6	43–55
TH1 CD4⁺CD45RA⁻/CXCR3⁺CXCR5⁻ (%)		NA	61	35.3–61
TH2 CD4⁺CD54RA⁻/CCR4⁺CCR6⁻ (%)		NA	7.5	4.4–13
TH17 CD4⁺CD45RA⁻/CCR4⁺CCR6⁺ (%)		NA	9.8	5.5–16.5
Follicular helper CD4⁺CD45RA⁻/CXCR5⁺ (%)		NA	15.6	16.3–30.2
Treg CD4⁺/CD25⁺CD127^LOW (%)		NA	9.5	4.2–10.5
CD8⁺ (/μl)		924	624	330–920
Naive CD8⁺/CCR7⁺CD45RA⁺ (%)		77	82	40–75
Central memory CD8⁺/CCR7⁺CD45RA⁻ (%)		3	1.4	2–7
Effector memory CD8⁺/CCR7⁻CD45RA⁻ (%)		12	8.1	11–20
Terminal effector CD8⁺/CCR7⁻CD45RA⁺ (%)		8	8.5	7–32
NK cells
CD16⁺CD56⁺ (/μl)		342	149	70–480
B lymphocytes
CD19⁺ (/μl)		548	478	193–628
Naive B cells (CD27⁻IgD⁺) (%)		92	92	61.6–87.4
Memory B cells (CD27⁺) (%)		3	7.6	7–29
Unswitched memory CD27⁺IgD⁺ (%)		2	5.7	2.6–13.4
Switched memory CD27⁺IgD⁻ (%)		2	1.6	4–21.2
Transitional CD24⁺⁺CD38⁺⁺ (%)		9	4.9	3.9–7.8
Plasmablast CD24⁻CD38⁺⁺ (%)		0.2	0	0.3–1.7
CD19⁺ CD21⁻CD38⁻ (%)		1	0.8	0.9–3.3

		Patient		Reference values
Age at evaluation (years)	7	12	14
Serum Ig levels
IgG* (g/l)	5.8	6.24	11.43	6.98–15.6
IgA (g/l)	0.89	1.35	1.46	0.53–2.9
IgM (g/l)	0.52	0.67	0.72	0.31–1.62
Blood parameters
Hemoglobin (×10⁹/liter)		14.2	14.9	13–17
MCV (fl)		NA	88.4	78–96
Leukocytes (×10⁹/liter)		7.15	7.58	4.5–13
Platelets (×10⁹/liter)		315	291	150–450
Monocytes (×10⁹/liter)		NA	0.75	0.3–1
Neutrophils (×10⁹/liter)		3.97	4.28	2–8
T lymphocytes
CD3⁺(/μl)		2,534	1,729	1,000–2,200
CD3⁺CD4⁺(/μl)		1,404	922	530–1,300
Naive CD4⁺/CD45RA⁺ (%)		71	66.4	58–70
Memory CD4⁺/CD45RO⁺ (%)		29	33.6	34–67
CD4⁺/CD31⁺CD45RA⁺ (%)		49	49.6	43–55
TH1 CD4⁺CD45RA⁻/CXCR3⁺CXCR5⁻ (%)		NA	61	35.3–61
TH2 CD4⁺CD54RA⁻/CCR4⁺CCR6⁻ (%)		NA	7.5	4.4–13
TH17 CD4⁺CD45RA⁻/CCR4⁺CCR6⁺ (%)		NA	9.8	5.5–16.5
Follicular helper CD4⁺CD45RA⁻/CXCR5⁺ (%)		NA	15.6	16.3–30.2
Treg CD4⁺/CD25⁺CD127^LOW (%)		NA	9.5	4.2–10.5
CD8⁺ (/μl)		924	624	330–920
Naive CD8⁺/CCR7⁺CD45RA⁺ (%)		77	82	40–75
Central memory CD8⁺/CCR7⁺CD45RA⁻ (%)		3	1.4	2–7
Effector memory CD8⁺/CCR7⁻CD45RA⁻ (%)		12	8.1	11–20
Terminal effector CD8⁺/CCR7⁻CD45RA⁺ (%)		8	8.5	7–32
NK cells
CD16⁺CD56⁺ (/μl)		342	149	70–480
B lymphocytes
CD19⁺ (/μl)		548	478	193–628
Naive B cells (CD27⁻IgD⁺) (%)		92	92	61.6–87.4
Memory B cells (CD27⁺) (%)		3	7.6	7–29
Unswitched memory CD27⁺IgD⁺ (%)		2	5.7	2.6–13.4
Switched memory CD27⁺IgD⁻ (%)		2	1.6	4–21.2
Transitional CD24⁺⁺CD38⁺⁺ (%)		9	4.9	3.9–7.8
Plasmablast CD24⁻CD38⁺⁺ (%)		0.2	0	0.3–1.7
CD19⁺ CD21⁻CD38⁻ (%)		1	0.8	0.9–3.3

IgG*, under suboptimal IgG replacement therapy; MCV, mean corpuscular volume; NA, not available. Values above or below reference ranges are marked in bold.

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